A missing or corrupt Steam API file can break save functionality.
If the game fails to save while running, press Alt + Enter to switch to windowed mode. Navigate to the save directory (usually C:\Program Files (x86)\Steam\userdata\[YourID]\221040\remote ) and rename savedata.bin to savedata1.bin . Return to the game and attempt to save again; it should prompt you to create a new, functional save file. how to fix save game pc resident evil 6 steam top