Bioshock Randomizer

Most modern launchers have a "Softlock Prevention" hotkey (usually F5 or F8) that forces a quest objective to complete. Save often. Rotate your saves.

: It aligns with the lore of Rapture—unregulated splicing leads to unpredictable, unstable mutations. Exploring BioShock eleven years later - Destructoid

The goal is to break memorized routing and force creative problem-solving, greatly increasing replayability.