The film explores the "Frankenstein" trope—the danger of unchecked ambition and playing god. It also serves as a disturbing Freudian drama, examining parenthood through Elsa’s attempts to nurture Dren while dealing with her own childhood trauma.

For many viewers, watching movies in their native language or in a language they are comfortable with enhances their viewing experience. Farsi, also known as Persian, is the official language of Iran, Afghanistan, and Tajikistan, and there is a significant audience for Farsi dubbed or subtitled movies. The demand for movies like "Splice" in Farsi reflects a broader trend of audiences seeking content that can be enjoyed in their preferred linguistic and cultural context.